Research

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Author: San Giorgi, MRM - Latest update: 25-04-2021
Groningen Papilloma Studies has conducted a lot of research into laryngeal papillomatosis in recent years. There are several ongoing investigations. We are constantly working on new ideas to better understand and combat this disease. The studies published in international scientific journals are listed below.

Articles 2021
Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement.
Sidell DR, Balakrishnan K, Best SR, Zur K, Buckingham J, De Alarcon A, Baroody FM, Bock JM, Boss EF, Bower CM, Campisi P, Chen SF, Clarke JM, Clarke KD, Cocciaglia A, Cotton RT, Cuestas G, Davis KL, DeFago VH, Dikkers FG, Dossans I, Florez W, Fox E, Friedman AD, Grant N, Hamdi O, Hogikyan ND, Johnson K, Johnson LB, Johnson RF, Kelly P, Klein AM, Lawlor CM, Leboulanger N, Levy AG, Lam D, Licameli GR, Long S, Lott DG, Manrique D, McMurray JS, Meister KD, Messner AH, Mohr M, Mudd P, Mortelliti AJ, Novakovic D, Ongkasuwan J, Peer S, Piersiala K, Prager JD, Pransky SM, Preciado D, Raynor T, Rinkel RNPM, Rodriguez H, Rodríguez VP, Russell J, Scatolini ML, Scheffler P, Smith DF, Smith LP, Smith ME, Smith RJH, Sorom A, Steinberg A, Stith JA, Thompson D, Thompson JW, Varela P, White DR, Wineland AM, Yang CJ, Zdanski CJ, Derkay CS.
Laryngoscope. 2021 Jan 6. DOI Pubmed
Articles 2019
Age at diagnosis, but not HPV type, is strongly associated with clinical course in recurrent respiratory papillomatosis.
Buchinsky FJ, Valentino WL, Ruszkay N, Powell E, Derkay CS, Seedat RY, Uloza V, Dikkers FG, Tunkel DE, Choi SS, Mortelliti AJ, Campisi P, Ospina JC, Donne AJ, Sataloff RT, Conley SF, McClay JE, Friedman EM, Elden L, Tylor DA, Rosen CA, Smith LJ, Copley GJ, Karas DE, Schweinfurth JM, Myer CM 3rd, Wiatrak BJ, Dohar JE, Sobol SE, Bastian RW, Smith RJH, Smith ME, Wassie AM, Post JC, Ehrlich GD.
PLoS One. 2019 Jun 13;14(6):e0216697. eCollection 2019. DOI Pubmed
Prophylactic human papilloma virus vaccination in head and neck: indications and future perspectives.
Wierzbicka M, Berkhof JH, Dikkers FG.
Curr Opin Otolaryngol Head Neck Surg. 2019 Apr;27(2):85-90. DOI Pubmed
Articles 2017
Recurrent Respiratory Papillomatosis, more than two entities.
San Giorgi MRM, Dikkers FG.
J Infect Dis. 2017 Dec 27. DOI Pubmed
Quality and readability assessment of websites related to recurrent respiratory papillomatosis.
San Giorgi MRM, de Groot OS, Dikkers FG.
Laryngoscope. 2017 Oct;127(10):2293-2297. doi: 10.1002/lary.26521. Epub 2017 Feb 24. DOI Pubmed
Validation of the Distress Thermometer and Problem List in Patients with Recurrent Respiratory Papillomatosis.
San Giorgi MRM, Aaltonen LM, Rihkanen H, Tjon Pian Gi REA, van der Laan BFAM, Hoekstra-Weebers JEHM, Dikkers FG.
Otolaryngol Head Neck Surg. 2017 Jan;156(1):180-188. doi: 10.1177/0194599816668307. Epub 2016 Oct 3. DOI Pubmed
Articles 2016
Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis.
Tjon Pian Gi REA, San Giorgi MRM, Pawlita M, Michel A, van Hemel BM, Schuuring EM, van den Heuvel ER, van der Laan BFAM, Dikkers FG.
Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3231-6. doi: 10.1007/s00405-016-4085-3. Epub 2016 May 17. DOI Pubmed
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review.
San Giorgi MRM, Helder HM, Lindeman RS, de Bock GH, Dikkers FG.
Laryngoscope. 2016 Oct;126(10):2330-9. doi: 10.1002/lary.25898. Epub 2016 Apr 26. DOI Pubmed
Age of onset of Recurrent Respiratory Papillomatosis: a distribution analysis.
San Giorgi MRM, van den Heuvel ER, Tjon Pian Gi REA, Brunings JW, Chirila M, Friedrich G, Golusinski W, Graupp M, Horcasitas Pous RA, Ilmarinen T, Jackowska J, Koelmel JC, Ferran Vilà F, Weichbold V, Wierzbicka M, Dikkers FG.
Clin Otolaryngol. 2016 Oct;41(5):448-53. doi: 10.1111/coa.12565. Epub 2016 Feb 11. DOI Pubmed
Articles 2015
The clinical course of recurrent respiratory papillomatosis after the use of cidofovir is influenced by multiple factors.
San Giorgi MR, Tjon Pian Gi RE, Dikkers FG.
Eur Arch Otorhinolaryngol. 2015 Jul;272(7):1819-20. doi: 10.1007/s00405-014-3366-y. Epub 2014 Oct 29. DOI Pubmed
Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11.
Tjon Pian Gi RE, San Giorgi MR, Slagter-Menkema L, van Hemel BM, van der Laan BF, van den Heuvel ER, Dikkers FG, Schuuring EM.
Head Neck. 2015 nov; 37(11). doi: 10.1002/hed.23808. Epub 2014 sep 12. DOI Pubmed
Articles 2014
Change of Voice Handicap Index after treatment of benign laryngeal disorders.
Stuut M, Tjon Pian Gi RE, Dikkers FG.
Eur Arch Otorhinolaryngol. 2014 May;271(5):1157-62. doi: 10.1007/s00405-013-2773-9. Epub 2013 Oct 20. DOI Pubmed
Articles 2013
Letter to the editor regarding "systematic review of intralesional cidofovir dosing regimens in the treatment of recurrent respiratory papillomatosis".
Dikkers FG.
Int J Pediatr Otorhinolaryngol. 2013 Oct;77(10):1789. doi: 10.1016/j.ijporl.2013.08.016. Epub 2013 Aug 27. DOI Pubmed
Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients.
Tjon Pian Gi RE, Ilmarinen T, van den Heuvel ER, Aaltonen LM, Andersen J, Brunings JW, Chirila M, Dietz A, Ferran Vilà F, Friedrich G, de Gier HH, Golusinski W, Graupp M, Hantzakos A, Horcasitas R, Jackowska J, Koelmel JC, Lawson G, Lindner F, Remacle M, Sittel C, Weichbold V, Wierzbicka M,Dikkers FG.
Eur Arch Otorhinolaryngol. 2013 May;270(5):1679-87. doi: 10.1007/s00405-013-2358-7. Epub 2013 Feb 3. DOI Pubmed
Articles 2012
Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis.
Tjon Pian Gi RE, Halmos GB, van Hemel BM, van den Heuvel ER, van der Laan BF, Plaat BE,Dikkers FG.
Laryngoscope. 2012 Aug;122(8):1826-30. doi: 10.1002/lary.23344. Epub 2012 May 7. DOI Pubmed
Treatment of recurrent respiratory papillomatosis and adverse reactions following off-label use of cidofovir (Vistide®).
Tjon Pian Gi RE, Dietz A, Djukic V, Eckel HE, Friedrich G, Golusinski W, Hantzakos A, Lawson G, Remacle M, Rihkanen H, Dikkers FG.
Eur Arch Otorhinolaryngol. 2012 Feb;269(2):361-2. doi: 10.1007/s00405-011-1804-7. Epub 2011 Oct 22. DOI Pubmed
Articles 2008
Intralesional cidofovir does not increase the risk of laryngeal dysplasia or laryngeal carcinoma.
Dikkers FG.
Int J Pediatr Otorhinolaryngol. 2008 Oct;72(10):1581-2; author reply 1583. doi: 10.1016/j.ijporl.2008.05.013. Epub 2008 Jul 3. DOI Pubmed
Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis.
Broekema FI, Dikkers FG.
Eur Arch Otorhinolaryngol. 2008 Aug;265(8):871-9. doi: 10.1007/s00405-008-0658-0. Epub 2008 May 6. Review. DOI Pubmed
Articles 2006
Treatment of recurrent respiratory papillomatosis with microsurgery in combination with intralesional cidofovir--a prospective study.
Dikkers FG.
Eur Arch Otorhinolaryngol. 2006 May;263(5):440-3. Epub 2005 Nov 22. DOI Pubmed
Articles 1997
Herhaalde anesthesieën voor de behandeling van larynxpapillomen.
Koenders MEF, Dikkers FG, Rosingh HJ, de Vos R, Wierda JMKH.
Ned Tijdsch KNO-heelkd 1997;3:15-9.
Book chapters
Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis -an international retrospective study on 635 RRP patients. In: Ilmarinen T. Recurrent respiratory papillomatosis – causes and consequences.
Tjon Pian Gi REA, Ilmarinen T, van den Heuvel ER, Aaltonen LM, Andersen J, Brunings JW, Chirila M, Dietz A, Ferran Vilà F, Friedrich G, de Gier HHW, Golusinski W, Graupp M, Hantzakos A, Horcasitas R, Jackowska J, Koelmel JC, Lawson G, Lindner F, Remacle M, Sittel C, Weichbold V, Wierzbicka M, Dikkers FG on behalf of the RRP study group of the ELS (European Laryngological Society).
Proefschrift University of Helsinki 2013:85-93.
Aandoeningen van de larynx en trachea. In: de Vries N, Van de Heyning PH, Leemans CR. Leerboek Keel-Neus-Oorheelkunde en hoofd-halschirugie.
Delaere P, de Bodt M, van der Laan BFAM, Dikkers FG.
Houten: Bohn, Stafleu, van Loghum 2013;287-311.
Current management of laryngeal papillomatosis in adults and children. In: Rekurantna respiratorna papilomatoza.
Dikkers FG.
Dukic V, ed. Beograd: Partenon 2016; 11-28.
Recurrent Respiratory Papillomatosis and Narrow Band Imaging. In: Textbook of Laryngology.
Dikkers FG.
Kapoor Nerurkar N, Roychoudhury A, eds. New Delhi: Jaypee Brothers Medical Publishers 2017:222-30.
Recurrent Respiratory Papillomatosis and Human Papillomavirus. In: Durand M, Deschler D, eds. Infections of the Ears, Nose, Throat, and Sinuses.
Dikkers FG, Tjon Pian Gi REA, San Giorgi MRM.
Cham: Springer 2018:365-76.
Aandoeningen van de larynx en trachea. In: de Vries N, Van de Heyning PH, Leemans CR. Leerboek KNO en Hoofd-Halschirurgie, 3e druk.
Dikkers FG, Delaere P, de Bodt M, van der Laan BFAM.
Houten: Bohn, Stafleu, van Loghum 2019: 323-348
PhD theses
Recurrent respiratory papillomatosis - from diagnosis to treatment.
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Dr. R.E.A. Tjon Pian Gi
R.E.A Tjon Pian Gi.
University Groningen, 12 october 2016.
Recurrent respiratory papillomatosis - clinical course and psychosocial aspects.
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M.R.M. San Giorgi
M.R.M. San Giorgi.
University Groningen, 5 july 2017.